Collagen and Probiotics: Can you take together?


May 2, 2023


Medically Reviewed ✓


For accuracy by Dr. Cate, M.D., a board-certified family physician, biochemist, and NY Times Bestseller.

Dr. Cate's Takeaway

There’s no reason to expect that probiotics would interfere with collagen’s health effects, and vise versa. The best source for probiotics are live culture foods, like yogurt, fermented sauerkraut and pickles, and kimchi.

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Quick Summary

Collagen and probiotics can both provide better gut health and there’s no reason to believe that taken together will decrease efficacy. However, you should always strive to choose natural probiotic foods first, then supplement. If you favor probiotic supplements, choose refrigerated capsules to ensure viability. If you choose to take your refrigerated probiotic powder and collagen powder together, be aware that probiotics are highly sensitive to changes in pH, salt content, and temperature. You can’t really measure pH or salt changes, but you can avoid excessive changes in heat/cold when mixing with your collagen. Cool smoothies, yogurt, and plain water could be safe choices.

This idea of taking collagen with [fill-in-the-blank] tends to be a common question we field. It’s why we’ve written articles to debunk the myths around collagen and vitamin C and offered guidance in taking collagen with multivitamins.

We’re thankful to Frances for taking the time to send us this one:

Can collagen peptides be taken with probiotics or GI supplements?
— Frances

Since 60-70 million Americans are affected by digestive diseases according to the National Institutes of Health, this is absolutely worthy of exploring. But first, let’s address a simple question.

Is Collagen a Probiotic?

This question is a great way to start this conversation since collagen and probiotics have some shared benefits. It might seem easy and harmless to assume collagen is a probiotic, but it’s not.

Probiotics must, by definition, contain a living organism. Since collagen has no living organisms, it is not considered a probiotic.

Let’s now discuss the shared benefits of these two superfoods.

Shared Benefits of Collagen & Probiotics: Digestive Health

Whether you’re taking collagen with natural probiotics such as yogurt, fermented cheeses, and vegetables, or taking with a probiotic dietary supplement, you’re probably seeking overall gut health as one of the benefits you’re desiring.

And that’s the conundrum. And why you’re probably here.

    • Probiotics = gut health
    • Collagen = gut health (though collagen offers many more benefits)

Since collagen can help with digestive health, and probiotics do the same, could this be a problem?

Do their benefits cancel each other out?

Doldrums Satellite
Is this a doldrums, situation? (Image Credit: Wikipedia)

Could taking probiotics and collagen, like, cancel each other out?

Just like the doldrums (aka Intertropical Convergence Zone) cancel out the northern and southern hemisphere winds around the equator, leaving ships sometimes without wind for days, could the same be said about collagen and probiotics? Do they cancel each other out?

Though this nautical phenomenon is fun to reference, let’s shift this conversation back to nutrition and solicit help from Dr. Cate.

Is taking Collagen with Probiotics still Effective?

When it comes to mixing a scoop of collagen peptides with your probiotics, Dr. Cate, M.D. says there’s nothing to worry about with the probiotics impacting the efficacy of the collagen.

There’s no reason to expect that probiotics would interfere with collagen’s health effects.
— Dr. Cate, M.D.

Flipping the coin, she also states that collagen won’t have any negative impact on the probiotics, either. “Collagen won’t interfere with the health effects of probiotics”.


This is NOT a doldrums situation.


Choose Natural Probiotic Foods, First.

Natural Probiotic Foods

If you’re an existing customer or have simply been following us for a bit, you know we believe in getting your nutrition from food FIRST, then supplementing.

This manifesto doesn’t change with probiotics.

Hands down, the best source for probiotics is food such as yogurt, fermented sauerkraut, and pickles, kimchi, and kombucha. These are a foundational element to a balanced diet (Four Pillars of World Cuisine), and the only probiotics guaranteed to have living, beneficial organisms.

Throw in a scoop of unflavored collagen to a glass of kombucha. Natural probiotics + collagen protein is a fantastic combo!

Start with natural probiotic foods first when consuming collagen. Then, if you need to supplement (and we all need to at times), choose probiotic capsules — more on that below.

Choose Probiotic Capsules, Second.

Choose Probiotic Capsules over powder when taking with Collagen
To ensure maximum effectiveness, probiotic capsules with collagen is the most reliable combo.

Just like collagen supplements come in various forms, so do probiotics. The typical vehicle of delivery will typically be a capsule or powder.

Most probiotics are in capsules and that’s actually important for their viability.
— Dr. Cate, M.D.

If you go the probiotic supplement capsule route, ensure the capsules:

Once you choose capsules as your vehicle, taking with collagen (like one of our multi collagen supplements) is an absolute breeze.

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"Been using this multi collagen for 3 years and continue to experience positive benefits!"

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Mixing Probiotic Powder with Collagen Peptide Powder

Choosing probiotic capsules over probiotic powder is the absolute best way to avoid any efficacy issues.

The process is simple:

  1. Take a probiotic capsule.
  2. Take collagen however you want. Here’s how to use collagen powder, and if you’re wondering, there’s no best time to take collagen.

However, we realize powders can be an easier vehicle for both adults and kids — as we explored in collagen powder vs pills — since many people struggle with swallowing pills. If you’re a parent like myself, you know the legit objection kids have to swallowing pills. #lostcause.

Tips for taking probiotic powders with collagen powders

Mixing Collagen Powder and Probiotic Powder Supplements into Smoothie
A smoothie with Collagen + Probiotic powder is quite the duo.
  • Avoid excessive changes in temperature (e.g. Hot Coffee!) Remember, probiotics are sensitive to heat. So, adding a scoop of refrigerated probiotic powder to your hot morning collagen and coffee, tea, oatmeal, eggs, etc. could potentially kill the bacteria. This is throwing money away!
  • Keep mixing simple. Probiotics are very sensitive to changes in salt content and pH (the reason we recommend capsules) so if you do want to mix both powders, keep things very simple and avoid acidity (e.g. Orange Juice).

If you want to roll the dice and take both powders with food, here are some general ideas:

Collagen Peptides with GI supplements

Let’s quickly address the other part of Frances’ question.

Can collagen peptides be taken with GI supplements?
— Frances

Both enzyme supplements and probiotic supplements can help with GI health. “Enzymes enhance the digestion of foods, while probiotics help support the immune functions of the gut”, states Houston Enzymes.

Can you take collagen peptides with GI supplements?

The answer isn’t as simple as we explored above with probiotics.

“If your gastrointestinal supplements contain enzymes, they may chop up some of the bioactive peptides in collagen”, says Dr. Cate. “Unlike our normal digestive enzymes, which are not released until passing through the stomach, external enzymes can start breaking the stuff down if they’re mixed or swallowed together.”

Unlike a probiotic supplement, there could be an impact of consuming GI supplements directly with a collagen powder if enzymes are present. Be sure to check your supplement labels for enzymes.

“Other than that, feel free to consume together”, adds Dr. Cate.

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This Collagen College™ article created by:


Eric Sharp CMO

Eric Sharp

Eric discovered collagen back in 2019 (thanks to Charlie) and been a believer since. He brings 20+ years of digital marketing experience to the CB Supplements team. As CMO, he's directly responsible for crafting the CB Supplements positioning, content, branding, and overall marketing direction.



Dr. Cate

Dr. Cate Shanahan is our Medical & Scientific Advisor. She is a Board-certified Family Physician, biochemist trained at Cornell University, and New York Times Bestseller.

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